Polynucleotide treatment sounds technical, so the beginner question is fair: who actually looks into it? The sources point to a few groups, and they are worth sorting before you book anything.
People interested in skin rejuvenation
A real-life assessment of injectable polynucleotides in aesthetic medicine for skin rejuvenation is the most direct read for general skin goals. RealSelf at www.realself.com reports a provider noting that her patients love how smooth, tight, hydrated, glowing, and firm their skin is afterward. Treat that as one provider's account, not a promise.
People focused on one area or one concern
A prospective observational study of polynucleotide injections for periorbital rhytides looks at the skin around the eyes. Dermatology Times covers polynucleotide therapy in scar and burn management, a different use altogether.
Learning the name before the sales pitch
One article covers Rejuran, the salmon-DNA skin booster, and what PDRN does for aging skin. Read it first and you will recognize the terms when a clinic uses them.
The step that costs nothing
Write down what you want from your skin, then take that list to a licensed clinician. Whether polynucleotides fit you is their call, not a website's.